Polynucleotides treatment has been making headlines across UK aesthetics clinics. In discussions about anti-ageing, it has been framed as a gentler alternative to traditional fillers or lasers. But what does it actually do? Is it really derived from salmon DNA? And is it right for you?
This blog explores polynucleotides in plain English, drawing on recent dermatology insights and experience from clinics across the UK.
What is a polynucleotides treatment?
Polynucleotides are chains of DNA and RNA fragments, typically extracted from purified fish sources. When injected into the skin, these molecules act as biostimulants – signalling the body to regenerate tissue and stimulate collagen production.
They’re not volume-fillers. Instead, they focus on:
- Stimulating fibroblast cells (which produce collagen and elastin)
- Improving hydration by retaining water in the skin
- Reducing inflammation and promoting cellular repair
- Encouraging skin tissue regeneration over time
The result? Skin that looks firmer, brighter, and more resilient – but still natural.
What does salmon DNA have to do with it?
Yes, it’s true – most polynucleotides treatment injections use purified DNA from salmon or trout. Don’t let that put you off. The raw material is highly processed and medical-grade, designed for use in pharmaceutical and regenerative medicine.
In fact, the body doesn’t treat these molecules as foreign. Instead, it recognises them as helpful signals for tissue repair and healing. Clinical research supports the safety and efficacy of these formulations across a range of cosmetic and medical applications.
What skin concerns can it help with?
Polynucleotides treatment is particularly helpful for people looking to:
- Reduce fine lines and wrinkles (especially under the eyes)
- Improve skin texture and elasticity
- Boost hydration in dry or sun-damaged skin
- Minimise the appearance of dark circles
- Support recovery from acne, scarring, or rosacea
It’s often used in the face, neck, and hands – and can be safely combined with other treatments, such as Profhilo or microneedling.
How many sessions will I need?
Most clinics recommend a course of 2–3 sessions, spaced around three weeks apart. Some clients see noticeable improvements in skin quality after the first session, but the best results tend to build gradually as collagen and elastin production increase.
Aftercare is straightforward, with minimal downtime. You may experience slight redness, swelling or bruising at the injection site, but these usually subside within a day or two.
How does it compare to Profhilo?
While both treatments hydrate and stimulate collagen, the mechanism is different:
Profhilo:
- Uses stabilised hyaluronic acid
- Focuses on hydration and superficial skin tightening
- Injected in five key points on each side of the face
Polynucleotides:
- Use DNA fragments to activate cell regeneration
- Target deeper tissue repair and anti-inflammatory effects
- Injected more precisely depending on skin concern
Some people choose to alternate or combine the two treatments for complementary benefits.
Is it safe?
Yes – when carried out by a trained medical practitioner. Polynucleotide products have been used in European aesthetic medicine for years and are CE-marked for safety.
They are typically well-tolerated, even by sensitive skin types, and the risk of allergic reaction is very low due to the high level of purification.
Is it right for me?
If you’re looking for a more regenerative approach to skin ageing – one that works with your body rather than masking it – this could be a great option.
It’s especially suited to people who:
- Feel their skin looks tired or dull
- Are seeing early signs of ageing, but don’t want volume-based fillers
- Have sensitive or redness-prone skin
- Are interested in natural-looking results
Typical results from UK clinics
Clients report:
- Smoother under-eye area with reduced puffiness
- Brighter skin tone and fewer visible pores
- Softer lines around the mouth and forehead
- Firmer, more hydrated skin on the neck and décolletage
As with all injectable treatments, individual results vary – but polynucleotide injections are gaining a strong reputation among both clinicians and clients.
FAQs
Is there any downtime?
Minimal. You may have a little swelling or redness at the injection points, but most people return to normal activities the same day.
Does it hurt?
The procedure involves small injections, but a numbing cream is usually applied beforehand. Most clients describe it as mildly uncomfortable rather than painful.
How long do results last?
After the initial course, maintenance treatments every 4–6 months are often recommended to sustain results.
How much does it cost?
Pricing varies by clinic, practitioner, and area treated. In Surrey clinics, you can typically expect to pay around £250–£350 per session.
Can I combine it with other treatments?
Yes. It works well alongside Profhilo, microneedling, chemical peels and other skin boosters – but you should always follow a personalised plan from your practitioner.
Polynucleotides treatments are a step forward in regenerative skin care – combining the power of molecular biology with a subtle, natural finish.
Book an appointment today at our Thames Ditton skin clinic in Surrey today and find out if it’s right for your skin.
This article is intended for informational purposes only and should not be considered medical advice. Always consult a qualified practitioner.