Injectable treatments have come a long way in the last decade. Most people in the UK are familiar with options like dermal fillers and anti-wrinkle injections – whether it’s to smooth fine lines or bring back a little lost volume. But while these treatments can give great results, they’re more about adding something in than building something up. 

If you’re looking to improve the quality of your skin – not just the plumpness – there’s a new regenerative option creating real buzz: polynucleotide injections. And at Little Foray, we’re proud to be offering this next-generation treatment in our calm, welcoming skin clinic in Thames Ditton, Surrey. 

So, what exactly are polynucleotides? 

In simple terms, polynucleotides are long chains of the molecules that make up DNA and RNA. When they’re purified and used as injectables, they don’t just sit under the skin adding volume – they work deeper. These clever little molecules act as bio-stimulators, gently waking up your body’s own natural repair processes. 

Most aesthetic formulations use highly purified fish DNA (often from salmon), because it closely resembles human DNA and is brilliantly biocompatible. Once injected, polynucleotides encourage your skin’s fibroblasts to get to work – producing more collagen and elastin, boosting hydration, and even improving microcirculation. 

Polynucleotides: A regenerative alternative to fillers 

Unlike traditional hyaluronic acid-based fillers – which are great for hydration and volume – polynucleotides focus on regeneration. They’ve actually been used in medical settings for years to help with wound healing and joint repair. In aesthetic treatments, they do everything from calming inflammation to improving skin texture and structure. 

So if you’re not after a dramatic change but do want to look fresher, healthier and well-rested, this could be a brilliant fit. 

Can you combine polynucleotides with Profhilo? 

Absolutely – and many of our clients do. Think of polynucleotides as the deep repair crew and Profhilo as the hydration boost. For example, we often combine the two for clients looking to tackle under-eye hollowness and crepiness. The polynucleotides help rebuild the strength of the skin, while Profhilo adds hydration and glow. We’ll always create a plan that’s tailored to you and your skin goals. 

What to expect from polynucleotides treatment 

Your comfort and safety always come first at Little Foray. Before your appointment, we’ll chat through your medical history, any allergies and what you’re hoping to achieve. 

On the day, we cleanse the skin and apply a numbing cream to keep things comfortable. The injections themselves only take 10–15 minutes using a very fine needle, and you’re usually in and out within the hour. You might notice tiny bumps at each injection point straight afterwards, but they’ll settle quickly – usually within a couple of days. 

The magic happens gradually. You may start to notice brighter, smoother skin from around the three-week mark. Results continue to build over the following weeks as your collagen production increases. With good skincare (and sunscreen!), the effects can last 6–9 months, with occasional top-ups to maintain that glow. 

The Benefits of Polynucleotides 

Clients – and clinicians – love them because they work with your skin, not against it. Some of the reported benefits include: 

• Boosted hydration and bounce – collagen and elastin get a natural nudge. 

• Fewer fine lines – the skin structure improves from within. 

• Brighter eyes – under-eye puffiness and dark circles often reduce thanks to better microcirculation. 

• Smoother scars – especially for acne scars or stretch marks. 

• Calmer skin – their anti-inflammatory powers can help with sensitivity and redness. 

Where can polynucleotides be used? 

They’re incredibly versatile. We regularly treat: 

• Under-eye hollows and dark circles 

• Face, neck and décolletage 

• Hands and other areas of crepey or thinning skin 

They’re especially useful in delicate areas where fillers may be too heavy or risky. 

A real-world example from our Surrey clinic 

One of our lovely clients in her late 30s came in recently, juggling work, family and life in general. She didn’t want a drastic change – just to look a little less tired. After a full consultation, she chose polynucleotide injections for her under-eyes. 

The appointment took under an hour, and she was straight back to work the next day. By week three, she was already getting compliments. Her friends couldn’t quite put their finger on it – they just said she looked well. And that’s exactly the kind of result polynucleotides deliver: natural, radiant, and confidence-boosting. 

Are polynucleotides safe and suitable for me? 

Polynucleotide treatments are considered very safe and well tolerated for most skin types – but a consultation is essential. You won’t be suitable if you have a fish allergy (since the DNA is usually salmon-derived) or an active skin infection. We’ll talk through everything beforehand and make sure this is the right choice for you. 

Possible side effects 

These are usually mild and short-lived: 

• Redness, swelling or small bumps that settle within a couple of days 

• Occasional bruising, especially in sensitive areas like the under-eyes 

• Temporary sensitivity 

Because this treatment is regenerative – not volumising – it carries a much lower risk of complications than traditional fillers. Choosing an experienced, medically qualified practitioner (like ours!) helps keep things safe, smooth and professional. 

Is this treatment right for you? 

You might love polynucleotide injections if you: 

✔ Have thinning or crepey skin 
✔ Want to improve under-eye concerns without adding volume 
✔ Are dealing with post-acne marks or stretch marks 
✔ Prefer a natural result that builds over time 
✔ Can commit to a short treatment plan with gradual results 

At Little Foray, we’ll always build a plan that works with your skin, your schedule and your goals. We often combine polynucleotides with Profhilo, microneedling or other advanced skin boosters to really elevate the results. 

Ready to try skin-first rejuvenation? 

Polynucleotides aren’t about instant fixes or frozen foreheads. They’re about rebuilding skin health from within – gently, naturally, and effectively. If you’re curious about what they could do for your skin, come and see us for a no-pressure consultation at our Thames Ditton clinic. 

We’re here to guide you every step of the way – and help you glow confidently, on your terms. 

👉 Book your consultation today or pop in to chat with our team about whether polynucleotides are the right next step in your skincare journey. 

This article is intended for informational purposes only and should not be considered medical advice. Always consult a qualified practitioner.