Non-surgical injectables have transformed modern skincare. Treatments like profhilo and the newer polynucleotide treatment injections promise fresher, healthier skin without changing your features — no frozen foreheads or puffed-up cheeks here.
But with so many options out there, it’s easy to feel unsure about which treatment suits your skin best. In this guide, we’ll break down how both work, who they’re best suited to, and why more and more clients at our Surrey clinic are choosing to combine the two.
You’ll find honest info, real-life examples, and friendly advice to help you feel confident about your next step.
What is profhilo?
Often nicknamed the “injectable moisturiser,” profhilo is made from stabilised hyaluronic acid (ha) – the same stuff your body naturally produces to keep your skin plump and hydrated.
But unlike traditional fillers, profhilo doesn’t add volume or change shape. Instead, it spreads evenly under the skin to deeply hydrate and stimulate collagen and elastin production. The result? Firmer, glowier skin that still looks 100% like you.
Treatment plan:
Two sessions, one month apart, with maintenance top-ups every six months.
When to expect results:
You’ll usually notice a visible glow from weeks four to six, with results lasting up to six months.
Profhilo perks
✅ intense hydration and radiance
✅ firmer, bouncier skin without volume
✅ subtle lift and glow
✅ quick results, minimal downtime
✅ great for face, neck, hands and décolletage
Example:
A 34-year-old client from Molsey, Surrey wants a refresh before a big summer wedding. She’s not ready for anything dramatic – just a boost. Profhilo is perfect: two appointments, barely any downtime, and a radiant glow just in time for the big day. She’s back at work the next morning with only a few tiny bumps that fade fast.
What are polynucleotide treatments?
Polynucleotide treatments are the new kid on the injectable block — but they’re making waves for all the right reasons.
Derived from purified DNA fragments (usually salmon – trust us, your skin loves it), they act as biostimulants. Instead of adding anything artificial, they gently prompt your skin to repair itself — boosting collagen, reducing inflammation, and improving texture from the inside out.
Polynucleotide treatment plan:
Three sessions, spaced three to four weeks apart, with maintenance every 9–12 months.
When to expect results:
You’ll start to see subtle improvements within a few weeks, with continued gains over several months.
Polynucleotide treatment perks
✅ stimulates collagen and elastin for stronger skin
✅ great for acne scars, rosacea and sun damage
✅ helps reduce puffiness and dark circles under the eyes
✅ long-lasting results – up to 12 months
✅ suitable for sensitive, mature or fragile skin
Example:
A 53-year-old gardening enthusiast from Richmond visits us after noticing sun damage, redness, and scarring from old breakouts. She’s not in a rush – she just wants stronger, healthier skin long term. Polynucleotides are ideal: they support deep repair and leave her skin calmer and more resilient over time. No dramatic changes, just healthier skin that holds up better in the elements.
Key differences at a glance
| Feature | Profhilo | Polynucleotides |
| Composition | Hyaluronic acid | Purified salmon dna fragments |
| Primary action | Deep hydration, collagen stimulation | Cellular regeneration, inflammation reduction |
| Treatment plan | 2 sessions (1 month apart) | 3 sessions (3–4 weeks apart) |
| Maintenance | Every 6 months | Every 9–12 months |
| Results timeline | Fast – 4 to 6 weeks | Gradual – weeks to months |
| Best for | Dull, dehydrated, crepey skin | Thin, scarred or inflamed skin (e.g. Under-eyes, rosacea) |
Which one’s right for you?
There’s no one-size-fits-all answer — and that’s why we take the time to talk it through with you in person at little foray. Here’s a quick guide to help you reflect:
Choose Profhilo if you:
- Want a fast hydration hit with minimal appointments
- Need a quick glow-up before a big event
- Have dull, tired, or crepey skin
- Want to maintain youthful bounce without changing your facial shape
Choose Polynucleotide treatments if you:
- Want to strengthen fragile or damaged skin
- Are tackling post-acne marks, under-eye hollows, or rosacea
- Prefer long-term repair and resilience over a short-term glow
- Have mature or sun-damaged skin needing deeper support
Or… choose both
Yes, they play well together. In fact, many of our clients opt to combine both treatments for the ultimate glow-meets-repair plan.
A typical protocol might look like this:
- Two Polynucleotide sessions to kick-start repair
- One Profhilo session a month later to add hydration and radiance
The exact plan depends on your skin’s needs — and our experienced team will always talk it through with you first.
What about safety and downtime?
Both treatments are considered very safe when carried out by qualified practitioners (like ours).
You might experience:
- Mild redness or swelling at the injection sites
- Tiny bumps that settle within 24–48 hours
- Occasional bruising, especially in delicate areas
Because both treatments work with your body, there’s little risk of looking “done” or overfilled. Most people head back to work or daily life the next day.
Important: we don’t treat clients who are pregnant or breastfeeding, and we’ll always take time to review your medical history in full at your consultation.
Let’s find what works for you
Injectables aren’t about trends — they’re about what you want your skin to feel like. Whether you’re drawn to the glow of Profhilo, the deep repair of Polynucleotides, or a combination of both, the team at Little Foray is here to help you make a confident, informed choice.
Book your consultation today at our Surrey skin clinic in Thames Ditton and let’s create a personalised plan that fits you perfectly.
Your skin. Your pace. Your results.
This article is intended for informational purposes only and should not be considered medical advice. Always consult a qualified practitioner.